OMNI Lab Publications

Liu C, Cardenas-Rivera A, Teitelbaum S, Birmingham A, Alfadhel M, Yaseen MA
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Alzheimers Res Therapy
Accepted
2024
DOI Link
Sugimoto K, Yang J, Fischer P, Takizawa T, Mulder IA, Qin T, Erdogan TD, Yaseen MA, Sakadzic S, Chung DY, Ayata C
Optogenetic spreading depolarizations do not worsen acute ischemic stroke outcome
Stroke
54
1110-1119
2023
DOI Link
Fischer P, Tamim I, Sugimoto K, Morais A, Imai T, Takizawa T, Qin T, Schlunk F, Endres M, Yaseen MA, Chung DY, Sakadzic S, Ayata C
Spreading depolarizations suppress hematoma growth in hyperacute intracerebral hemorrhage in mice
Stroke
54
2640-2651
2023
DOI Link
Pian Q, Alfadhel M, Tang J, Lee GV, Li B, Fu B, Ayata Y, Yaseen MA, Boas DA, Secomb TW, Sakadzic S
Cortical microvascular blood flow velocity mapping by combining light scattering optical coherence tomography and two-photon microscopy
J Biomed Opt
28
076003
2023
DOI Link
Liu C, Chisholm A, Fu B, Su C T.-Y., Şencan İ, Sakadžić S, Yaseen MA
Quantitation of cerebral oxygen tension using phasor analysis and phosphorescence lifetime imaging microscopy (PLIM)
Biomed. Opt. Exp.
12
4192-4206
2021
DOI Link
Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan S, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakadzic S, Boas DA, Whalen MJ, Ayata C
Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice
J Cereb Blood Flow Metab
41
975-985
2021
DOI Link
Oka F, Sadeghian H, Yaseen MA, Fu B, Kura S, Qin T, Sakadzic S, Sugimoto K, Inoue T, Ishihara H, Nomura S, Suzuki M, Ayata.C
Intracranial pressure spikes trigger spreading depolarizations
Brain
45
194-207
2021
DOI Link
Mächler P, Broggini T, Mateo C, Thunemann M, Fomin-Thunemann N, Doran PR, Sencan I, Kilic K, Desjardins M, Uhlirova H, Yaseen MA, Boas DA, Linninger AA, Vergassola M, Yu X, Lewis LD, Polimeni JR, Rosen BR, Sakadzic S, Buxton RB, Lauritzen M, Kleinfeld D, Devor A
A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI
Curr Opinion Biomed Eng
18
100273
2021
DOI Link
Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C
Focal subcortical white matter lesions disrupt resting state cortical interhemispheric functional connectivity in mice
Cereb Cortex
31
4958-4969
2021
DOI Link
Fischer P, Sugimoto K, Chung DY, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA, Sakadzic S, Ayata C
Rapid hematoma growth triggers spreading depression polarizations in experimental intracortical hemorrhage
J Cereb Blood Flow Metab
41
1264-1276
2021
DOI Link
Xie H, Chung DY, Kura S, Sugimoto K, Aykan SA, Wu Y, Sakadžić S, Yaseen MA, Boas DA, Ayata C.
Differential effects of anesthetics on resting state functional connectivity in the mouse.
J Cereb Blood Flow Metab.
40
875-84
2020
DOI Link
Sencan I, Esipova T, Kiliç K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadžić S.
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.
J Cereb Blood Flow Metab.
2020
DOI Link
Böhm M, Chung DY, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadžić S, Yaseen MA, Ayata C.
Local and remote stimulus-response characteristics, and uncoupling by spreading depression.
J Cereb Blood Flow Metab.
40
808-22
2020
DOI Link
Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aslihan Aykan S, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadžić S, Ayata C.
Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations.
Stroke
51
2526-35
2020
DOI Link
Bartosik PB, Fitzgerald JE, El Khatib M, Yaseen MA, Vinogradov SA, Niedre M.
Prospects for the Use of Upconverting Nanoparticles as a Contrast Agent for Enumeration of Circulating Cells in vivo.
Int J Nanomedicine.
15
1709-19
2020
DOI Link
Li B, Ohtomo R, Thunemann M, Adams SR, Yang J, Fu B, Yaseen MA, Ran C, Polimeni JR, Boas DA, Devor A, Lo EH, Arai K, Sakadžić S.
Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion.
J Cereb Blood Flow Metab.
40
501-12
2020
DOI Link
Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžić S, Ayata C.
Determinants of Optogenetic Cortical Spreading Depolarizations.
Cereb Cortex.
29
1150-61
2019
DOI Link
Li B, Esipova TV, Sencan I, Kiliç K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Østergaard L, Devor A, Boas DA, Vinogradov SA, Sakadžić S.
More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.
Elife.
8
2019
DOI Link
Gómez CA, Fu B, Sakadžić S, Yaseen MA.
Cerebral metabolism in a mouse model of Alzheimer's disease characterized by two-photon fluorescence lifetime microscopy of intrinsic NADH.
Neurophotonics.
5
45008
2018
DOI Link
Gómez CA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžić S, Yaseen MA.
Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex.
PLoS One.
13
e0194578
2018
DOI Link
Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžić S, Ayata C.
Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice.
J Neurosci Methods.
309
143-6
2018
DOI Link
Sencan I, Esipova TV, Yaseen MA, Fu B, Boas DA, Vinogradov SA, Shahidi M, Sakadžić S.
Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice.
J Biomed Opt.
23
9-Jan
2018
DOI Link
Yaseen MA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžić S.
Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo
Biomed Opt Express.
8
2368-85
2017
DOI Link
Polasek M, Yang Y, Schühle DT, Yaseen MA, Kim YR, Sung YS, Guimaraes AR, Caravan P.
Molecular MR imaging of fibrosis in a mouse model of pancreatic cancer.
Sci Rep.
7
8114
2017
DOI Link
Wang H, Akkin T, Magnain C, Wang R, Dubb J, Kostis WJ, Yaseen MA, Cramer A, Sakadžić S, Boas D.
Polarization sensitive optical coherence microscopy for brain imaging.
Opt Lett.
41
2213-6
2016
DOI Link
Sakadžić S, Yaseen MA, Jaswal R, Roussakis E, Dale AM, Buxton RB, Vinogradov SA, Boas DA, Devor A.
Two-photon microscopy measurement of cerebral metabolic rate of oxygen using periarteriolar oxygen concentration gradients.
Neurophotonics.
3
45005
2016
DOI Link
Uhlirova H, Kiliç K, Tian P, Sakadžić S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A.
The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.
Philos Trans R Soc Lond B Biol Sci.
371
2016
DOI Link
Yaseen MA, Srinivasan VJ, Gorczynska I, Fujimoto JG, Boas DA, Sakadžić S.
Multimodal optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism.
Biomed Opt Express.
6
4994-5007
2015
DOI Link
Gagnon L, Sakadžić S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA.
Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe.
J Neurosci.
35
3663-75
2015
DOI Link
Gagnon L, Sakadžić S, Lesage F, Mandeville ET, Fang Q, Yaseen MA, Boas DA.
Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography.
Neurophotonics.
2
15008
2015
DOI Link
Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C.
A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.
Chem Commun (Camb).
50
11550-3
2014
DOI Link
Sakadžić S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA.
Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue.
Nat Commun.
5
5734
2014
DOI Link
Yaseen MA, Sakadžić S, Wu W, Becker W, Kasischke KA, Boas DA.
In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH.
Biomed Opt Express.
4
307-21
2013
DOI Link
Devor A, Sakadžić S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA.
Frontiers in optical imaging of cerebral blood flow and metabolism.
J Cereb Blood Flow Metab.
32
1259-76
2012
DOI Link
Moriggi L, Yaseen MA, Helm L, Caravan P.
Serum albumin targeted, pH-dependent magnetic resonance relaxation agents.
Chemistry.
18
3675-86
2012
DOI Link
Sakadžić S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA.
Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence.
J Vis Exp.
4
2011
DOI Link
Devor A, Sakadžić S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA.
"Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels.
J Neurosci.
31
13676-81
2011
DOI Link
Yaseen MA, Srinivasan VJ, Sakadžić S, Radhakrishnan H, Gorczynska I, Wu W, Fujimoto JG, Boas DA.
Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation.
J Cereb Blood Flow Metab.
31
1051-63
2011
DOI Link
Yaseen MA, Ermilov SA, Brecht HP, Su R, Conjusteau A, Fronheiser M, Bell BA, Motamedi M, Oraevsky AA.
Optoacoustic imaging of the prostate: development toward image-guided biopsy.
J Biomed Opt.
15
21310
2010
DOI Link
Yu J, Javier D, Yaseen MA, Nitin N, Richards-Kortum R, Anvari B, Wong MS.
Self-assembly synthesis, tumor cell targeting, and photothermal capabilities of antibody-coated indocyanine green nanocapsules.
J Am Chem Soc.
132
1929-38
2010
DOI Link
Sukhotinsky I, Yaseen MA, Sakadžić S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C.
Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range.
J Cereb Blood Flow Metab.
30
1168-77
2010
DOI Link
Sakadžić S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA.
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue.
Nat Methods.
7
755-9
2010
DOI Link
Yaseen MA, Yu J, Jung B, Wong MS, Anvari B.
Biodistribution of encapsulated indocyanine green in healthy mice.
Mol Pharm.
6
1321-32
2009
DOI Link
Yaseen MA, Srinivasan VJ, Sakadžić S, Wu W, Ruvinskaya S, Vinogradov SA, Boas DA.
Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy.
Opt Express.
17
22341-50
2009
DOI Link
Yaseen MA, Yu J, Wong MS, Anvari B.
In-vivo fluorescence imaging of mammalian organs using charge-assembled mesocapsule constructs containing indocyanine green.
Opt Express.
16
20577-87
2008
DOI Link
Yaseen MA, Yu J, Wong MS, Anvari B.
Laser-induced heating of dextran-coated mesocapsules containing indocyanine green.
Biotechnol Prog.
23
1431-40
2007
DOI Link
Yaseen MA, Yu J, Wong MS, Anvari B.
Stability assessment of indocyanine green within dextran-coated mesocapsules by absorbance spectroscopy.
J Biomed Opt.
12
64031
2007
DOI Link
Dai T, Yaseen MA, Diagaradjane P, Chang DW, Anvari B.
Comparative study of cryogen spray cooling with R-134a and R-404a: implications for laser treatment of dark human skin.
J Biomed Opt.
11
41116
2006
DOI Link
Diagaradjane P, Yaseen MA, Yu J, Wong MS, Anvari B.
Synchronous fluorescence spectroscopic characterization of DMBA-TPA-induced squamous cell carcinoma in mice.
J Biomed Opt.
11
14012
2006
DOI Link
Diagaradjane P, Yaseen MA, Yu J, Wong MS, Anvari B.
Autofluorescence characterization for the early diagnosis of neoplastic changes in DMBA/TPA-induced mouse skin carcinogenesis.
Lasers Surg Med.
37
382-95
2005
DOI Link
Dai T, Diagaradjane P, Yaseen MA, Pikkula BM, Thomsen S, Anvari B.
Laser-induced thermal injury to dermal blood vessels: analysis of wavelength (585 nm vs. 595 nm), cryogen spray cooling, and wound healing effects.
Lasers Surg Med.
37
210-8
2005
DOI Link